The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Mar. 01, 2018
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Institut Jean Paoli & Irene Calmettes, Marseilles, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Universite D'aix Marseille, Marseilles, FR;
Marc Lopez, Marseill, FR;
INSERM (Institut National de la Santé et de la Recherche Médicale, Paris, FR;
INSTITUT JEAN PAOLI & IRENE CALETTES, Marseilles, FR;
CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
UNIVERSITE D'AIX MARSEILLE, Marseilles, FR;
Abstract
The present invention relates to a new antibody anti-nectin-4. Nectin-4 is a tumor-associated antigen overexpressed in several cancers and notably in 30%, 49% and 86% of breast, ovarian and lung carcinomas, respectively, which are tumors of bad prognosis. Treatments remain still elusive. That's why the inventors developed a new targeted therapy based on an antibody having specificity to nectin-4 (called 14A5.2 mab). Indeed, the inventors selected this antibody for its intrinsic prophylactic anti-metastatic properties and also for the treatment of localized primary and metastatic cancer. More, the 14A5.2 mab could be indicated for the treatment of cancer resistant to ASG-22ME (from Astellas company). Thus, the invention relates to the 14A5.2 mab and its uses thereof.