The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Aug. 04, 2011
Ravi V. Bellamkonda, Marietta, GA (US);
Anjana Jain, Worcester, MA (US);
Nassir Mokarram-dorri, Durham, NC (US);
Barun Brahma, Atlanta, GA (US);
Ravi V. Bellamkonda, Marietta, GA (US);
Anjana Jain, Worcester, MA (US);
Nassir Mokarram-Dorri, Durham, NC (US);
Barun Brahma, Atlanta, GA (US);
GEORGIA TECH RESEARCH CORPORATION, Atlanta, GA (US);
CHILDREN'S HEALTHCARE OF ATLANTA, INC., Atlanta, GA (US);
Abstract
Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.