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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11273237 B1

PDFFull Text
Date of Patent:
Mar. 15, 2022

Filed:

Aug. 31, 2017

Method for producing porous substrate comprising bioabsorbable polymer that contains heparin, porous substrate comprising bioabsorbable polymer that contains heparin, and artificial blood vessel

Applicant:

Gunze Limited, Ayabe, JP;

Inventors:

Hidetaka Nakayama, Kyoto, JP;

Toshiharu Shinoka, Tokyo, JP;

Shuhei Tara, Tokyo, JP;

Tadahisa Sugiura, Tokyo, JP;

Assignee:

GUNZE LIMITED, Kyoto, JP;

Attorney:

Hamre, Schumann, Mueller & Larson, P.C.

Primary Examiner:

Nahida Sultana

Int. Cl.
CPC ...
A61L 27/56 (2006.01); A61L 27/14 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); B29C 67/20 (2006.01); B29K 67/00 (2006.01); B29K 105/00 (2006.01); B29L 31/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/56 (2013.01); A61L 27/14 (2013.01); A61L 27/507 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); B29C 67/20 (2013.01); A61L 2300/236 (2013.01); B29K 2067/04 (2013.01); B29K 2105/0035 (2013.01); B29K 2995/006 (2013.01); B29L 2031/7534 (2013.01);
Abstract

The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel. The present invention provides a method for producing a porous substrate containing a bioabsorbable polymer and heparin, including: a solution preparing step of preparing a heparin-bioabsorbable polymer solution having heparin uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the heparin, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the heparin; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the heparin to provide a porous substrate containing the heparin.

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