The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
May. 24, 2018
National Cerebral and Cardiovascular Center, Osaka, JP;
Mariko Harada-Shiba, Osaka, JP;
Fumito Wada, Osaka, JP;
Satoshi Obika, Osaka, JP;
Tsuyoshi Yamamoto, Osaka, JP;
Keisuke Tachibana, Osaka, JP;
Tadayuki Kobayashi, Osaka, JP;
Kosuke Ito, Osaka, JP;
Motoki Sawamura, Osaka, JP;
National Cerebral and Cardiovascular Center, Osaka, JP;
Abstract
Provided is an oligonucleotide conjugate comprising an oligonucleotide and two or more linearly connected asialoglycoprotein receptor-binding molecules attached to the oligonucleotide, wherein the oligonucleotide comprises a locked nucleoside analog having a bridging structure between the 4' and 2′ positions, is complementary to a human PCSK9 gene, and has inhibitory activity on the expression of the human PCSK9 gene. The oligonucleotide conjugate of the present invention can be used in the field of pharmaceutical products, in particular, the field of the development and production of therapeutic agents for diseases associated with a high LDL cholesterol level.