The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Sep. 14, 2018
Applicant:
Instituto DE Medicina Molecular João Lobo Antunes, Lisbon, PT;
Inventors:
Goncalo Bernardes, Lisbon, PT;
Tiago Rodrigues, Lisbon, PT;
João Conde, Lisbon, PT;
Charlotte Baker, Lisbon, PT;
Assignee:
Instituto de Medicina Molecular João Lobo Antunes, Lisbon, PT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/445 (2006.01); A61P 35/00 (2006.01); A61K 31/4412 (2006.01); A61K 9/06 (2006.01); A61K 45/06 (2006.01); A61K 47/40 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4412 (2013.01); A61K 9/06 (2013.01); A61K 45/06 (2013.01); A61K 47/40 (2013.01); A61P 35/00 (2018.01);
Abstract
This invention relates to the finding that Piperlongumine compounds, such as Piperlongumine and analogues, derivatives and prodrugs thereof, are reversible, allosteric antagonists of transient receptor potential vanilloid 2 channel (TRPV2). Methods of treatment of conditions that are characterised by TRPV2 expression using Piperlongumine compounds and Piperlongumine compounds for use in such treatments are provided.