The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Aug. 31, 2018
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Harry C. Dietz, Towson, MD (US);
Benjamin Edward Kang, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4155 (2006.01); A61P 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4155 (2013.01); A61P 9/14 (2018.01);
Abstract
Transforming growth factor β (TGFβ) transcriptional responses are involved in the pathogenesis of aortic aneurism syndromes. Compositions that inhibit histone acetyltransferase activity normalize gene expression in the aorta, preserved aortic wall architecture and abrogated aneurism progression. Methods include the use of these compositions to epigenetically regulate abnormal expression and/or activity of TGFβ genes.