The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Jun. 10, 2019
Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, CN;
Yuelei Shen, Beijing, CN;
Yanan Guo, Beijing, CN;
Yang Bai, Beijing, CN;
Rui Huang, Beijing, CN;
Xiaofei Zhou, Beijing, CN;
Meiling Zhang, Beijing, CN;
Jiawei Yao, Beijing, CN;
Chaoshe Guo, Beijing, CN;
Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, CN;
Abstract
The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.