The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2022

Filed:

Nov. 08, 2017
Applicant:

Georgia Tech Research Corporation, Atlanta, GA (US);

Inventors:

Todd Sulchek, Atlanta, GA (US);

Alexander Alexeev, Atlanta, GA (US);

Bushra Tasadduq, Atlanta, GA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 15/10 (2006.01); G01N 1/34 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1056 (2013.01); B01L 3/502761 (2013.01); B01L 3/502776 (2013.01); G01N 1/34 (2013.01); G01N 33/5005 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/16 (2013.01); B01L 2400/086 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01);
Abstract

Embodiments of the present disclosure can include a method comprising: providing a plurality of cells to a microchannel, the microchannel coated in at least one cell adhesion entity and comprising a compressive surface and a first outlet, the compressive surface defining a compression gap, flowing the plurality of cells through the microchannel, wherein the flowing comprises: compressing the plurality of cells underneath the compressive surface; and exposing the plurality of cells to the at least one cell adhesion entity, wherein the exposing causes a first portion of the cells having a first adhesion property to temporarily bind to the cell adhesion entity; and collecting the first portion of cells at the first outlet; wherein the compression gap has a height of from 75% to 95% an average diameter of the plurality of cells.


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