The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Mar. 28, 2018
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Assignee:
Merck Sharp and Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 39/00 (2006.01); C12N 5/078 (2010.01); A61K 31/7088 (2006.01); A61K 35/18 (2015.01); C12N 7/00 (2006.01); C12N 5/071 (2010.01); C12N 9/22 (2006.01); C07K 4/04 (2006.01); C12N 5/07 (2010.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); C07K 4/04 (2013.01); C12N 5/06 (2013.01); C12N 5/0686 (2013.01); C12N 9/22 (2013.01); C12N 15/101 (2013.01); C12N 15/1017 (2013.01); A61K 2039/5254 (2013.01); C12N 2501/70 (2013.01); C12N 2501/73 (2013.01); C12N 2531/00 (2013.01); C12N 2533/12 (2013.01); C12N 2533/54 (2013.01); C12N 2533/78 (2013.01); C12N 2700/00 (2013.01); C12N 2770/24121 (2013.01); C12N 2770/24134 (2013.01); C12N 2770/24151 (2013.01);
Abstract
The present invention provides an efficient process for culturing viruses in the presence of an endonuclease and for producing vaccines, typically from live attenuated viruses, under conditions to reduce the presence of host cell DNA and eliminate the need for a post-harvest DNA digestion step.