The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Nov. 26, 2019
Wilson Wolf Manufacturing, New Brighton, MN (US);
Baylor College of Medicine, Houston, TX (US);
Juan F. Vera, Bellaire, TX (US);
Cliona M. Rooney, Bellaire, TX (US);
Ann M. Leen, Bellaire, TX (US);
John R. Wilson, New Brighton, MN (US);
Wilson Wolf Manufacturing, New Brighton, MN (US);
Baylor College of Medicine, Houston, TX (US);
Abstract
An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cmif the growth surface is not comprised of gas permeable material and up to 2 ml/cmif the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×10cells/cmat the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×10cells/cm.