The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Jul. 25, 2019
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Maria Amann, Duebendorf, CH;
Peter Bruenker, Hittnau, CH;
Christina Claus, Ennetbaden, CH;
Claudia Ferrara Koller, Zug, CH;
Sandra Grau-Richards, Birmensdorf, CH;
Christian Klein, Bonstetten, CH;
Viktor Levitski, Schlieren, CH;
Ekkehard Moessner, Kreuzlingen, CH;
Joerg Thomas Regula, Munich, DE;
Pablo Umana, Wollerau, CH;
Hofmann-La Roche Inc., Little Falls, NJ (US);
Abstract
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.