The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2022

Filed:

Apr. 08, 2020
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Xavier Valencia, Princeton, NJ (US);

John P. Throup, New Hope, PA (US);

Steven G. Nadler, Princeton, NJ (US);

Suzanne J. Suchard, Portland, OR (US);

Dominique Duchesne, Yardley, PA (US);

Xiaoni Liu, Yardley, PA (US);

Rong Shi, Princeton, NJ (US);

Diane E. Shevell, Westfield, NJ (US);

Jenny H. Xie, Princeton, NJ (US);

Marek Honczarenko, Princeton, NJ (US);

Assignee:

BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 47/60 (2017.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2818 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/31 (2013.01);
Abstract

Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.


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