The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Mar. 02, 2017
Applicant:
Roche Innovation Center Copenhagen A/s;
Inventors:
Assignee:
Roche Innovation Center Copenhagen A/S, Horsholm, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/16 (2006.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01);
Abstract
Stereodefined phosphorothioate oligonucleotides, related nucleoside monomers and methods of synthesis of both are described. The disclosed isobutyryl protected L-LNA-G monomers have following Formula 50 or 51 where Ris independently CHODMTr or CHOMMTr and R, when present, is cyanoethyl. The monomers have improved solubility and stability characteristics, resulting in improved efficacy in oligonucleotide synthesis.