IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11267819 B1

PDFFull Text
Date of Patent:
Mar. 08, 2022

Filed:

Jan. 09, 2020

Diamine derivatives as inhibitors of leukotriene a4 hydrolase

Applicant:

Celltaxis, Llc, Atlanta, GA (US);

Inventors:

Damian O. Arnaiz, El Sobrante, CA (US);

Greg Brown, Oakland, CA (US);

Emmanuel Claret, Besancon, FR;

Arwed Cleve, Berlin, DE;

David Davey, Landing, NJ (US);

William Guilford, Belmont, CA (US);

Seock-Kyu Khim, Orinda, CA (US);

Thomas Kirkland, Atascadero, CA (US);

Monica J. Kochanny, Benicia, CA (US);

Amy Liang, Vallejo, CA (US);

David Light, San Mateo, CA (US);

John Parkinson, Martinez, CA (US);

Guo Ping Wei, San Ramon, CA (US);

Bin Ye, Moraga, CA (US);

Assignee:

Celltaxsis, LLC, Atlanta, GA (US);

Attorneys:

Elmore Patent Law Group, P.C.

Mahreen Chaudhry Hoda

Carolyn S. Elmore

Primary Examiner:

Golam M Shameem

Int. Cl.
CPC ...
C07D 487/08 (2006.01); C07C 217/58 (2006.01); C07C 229/38 (2006.01); C07C 233/78 (2006.01); C07C 255/57 (2006.01); C07C 271/20 (2006.01); C07D 207/04 (2006.01); C07D 211/58 (2006.01); C07D 243/08 (2006.01); C07D 295/04 (2006.01); C07D 295/16 (2006.01); C07D 451/04 (2006.01); C07D 207/09 (2006.01); C07D 211/26 (2006.01); C07D 263/32 (2006.01); C07D 295/096 (2006.01); C07D 401/10 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07C 229/08 (2006.01); C07D 263/14 (2006.01); C07D 401/12 (2006.01); C07D 207/16 (2006.01); C07D 211/34 (2006.01); C07D 277/22 (2006.01); C07D 277/68 (2006.01); C07D 451/02 (2006.01);
U.S. Cl.
CPC ...
C07D 487/08 (2013.01); C07C 217/58 (2013.01); C07C 229/08 (2013.01); C07C 229/38 (2013.01); C07C 233/78 (2013.01); C07C 255/57 (2013.01); C07C 271/20 (2013.01); C07D 207/04 (2013.01); C07D 207/09 (2013.01); C07D 207/16 (2013.01); C07D 211/26 (2013.01); C07D 211/34 (2013.01); C07D 211/58 (2013.01); C07D 243/08 (2013.01); C07D 263/14 (2013.01); C07D 263/32 (2013.01); C07D 277/22 (2013.01); C07D 277/68 (2013.01); C07D 295/04 (2013.01); C07D 295/096 (2013.01); C07D 295/16 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 451/02 (2013.01); C07D 451/04 (2013.01); C07B 2200/07 (2013.01); C07C 2601/14 (2017.05);
Abstract

This invention is directed to compounds of formula (I): where r, q, R, R, R, R, R, R, R, R, R, R, R, R, and Rare described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene Ahydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

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