The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2022

Filed:

May. 17, 2017
Applicants:

Mirati Therapeutics, Inc., San Diego, CA (US);

Array Biopharma Inc., Boulder, CO (US);

Inventors:

John P. Fischer, Boulder, CO (US);

Jay Bradford Fell, Boulder, CO (US);

James F. Blake, Boulder, CO (US);

Ronald Jay Hinklin, Boulder, CO (US);

Macedonio J. Mejia, Boulder, CO (US);

Erik James Hicken, Boulder, CO (US);

Mark Joseph Chicarelli, Boulder, CO (US);

John J. Gaudino, Boulder, CO (US);

Guy P. A. Vigers, Boulder, CO (US);

Laurence E. Burgess, Boulder, CO (US);

Matthew Arnold Marx, San Diego, CA (US);

James Gail Christensen, San Diego, CA (US);

Matthew Randolph Lee, San Diego, CA (US);

Pavel Savechenkov, Boulder, CO (US);

Henry J. Zecca, Boulder, CO (US);

Tony P. Tang, Boulder, CO (US);

Assignees:

MIRATI THERAPEUTICS, INC., San Diego, CA (US);

ARRAY BIOPHARMA INC., Boulder, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 519/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 35/00 (2018.01); C07D 519/00 (2013.01); H05K 999/99 (2013.01);
Abstract

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.


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