The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
May. 19, 2020
Applicant:
Nektar Therapeutics, San Francisco, CA (US);
Inventors:
Michael D. Bentley, Huntsville, AL (US);
Sean M. Culbertson, Gurley, AL (US);
Samuel P. McManus, Huntsville, AL (US);
Assignee:
Nektar Therapeutics, San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 47/60 (2017.01); C08G 61/02 (2006.01); C07C 235/68 (2006.01); C07D 207/46 (2006.01); C07K 14/575 (2006.01); C08G 65/48 (2006.01); C08G 65/338 (2006.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); C08G 65/333 (2006.01); C08G 65/334 (2006.01); C08K 5/13 (2006.01); A61K 31/765 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 38/26 (2013.01); A61K 38/28 (2013.01); C07C 235/68 (2013.01); C07D 207/46 (2013.01); C07K 14/575 (2013.01); C08G 61/02 (2013.01); C08G 65/338 (2013.01); C08G 65/3348 (2013.01); C08G 65/33396 (2013.01); C08G 65/48 (2013.01); C08K 5/13 (2013.01); A61K 31/765 (2013.01); C08K 2201/012 (2013.01);
Abstract
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.