The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Sep. 29, 2016
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventor:
Denise L. Faustman, Boston, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2020.01); A61K 39/04 (2006.01); C12Q 1/6883 (2018.01); G01N 33/48 (2006.01); G01N 33/66 (2006.01); G01N 33/92 (2006.01); A61P 3/06 (2006.01); A61K 31/397 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 39/04 (2013.01); A61K 31/397 (2013.01); A61K 45/06 (2013.01); A61P 3/06 (2018.01); C12Q 1/6883 (2013.01); G01N 33/48 (2013.01); G01N 33/66 (2013.01); G01N 33/92 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/154 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/52 (2013.01);
Abstract
The invention provides methods of treating disease, such as hypercholesterolemia (e.g., by modulating serum lipids, such as cholesterol, low-density lipoproteins, high-density lipoproteins, and triglycerides) and hyperglycemia by administering Bacillus Calmette-Guerin (BCG). Methods of the invention also encompass the use of genomic, proteomic, and metabolomic analyses for determining the likelihood that a patient has disease or will respond to treatment (e.g., with BCG therapy), as well as for determining whether a patient previously administered BCG would benefit from BCG redosing.