The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2022

Filed:

Dec. 29, 2017
Applicant:

National Health Research Institutes, Zhunan, TW;

Inventors:

Hsin-Wei Chen, Zhunan, TW;

Chih-Hsiang Leng, Zhunan, TW;

Shih-Jen Liu, Zhunan, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 39/39 (2006.01); A61K 45/06 (2006.01); A61K 39/12 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
A61K 39/00115 (2018.08); A61K 39/001168 (2018.08); A61K 39/12 (2013.01); C07K 14/705 (2013.01); C07K 2319/00 (2013.01);
Abstract

Provided is a pharmaceutical composition, including an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. Also provided is a method of enhancing immunogenicity of an antigen, including conjugating the antigen with an antagonist of an Fc gamma receptor to form an antigen fusion protein. Also provided is a method of enhancing an immune response to an antigen in a subject, including administering to the subject an effective amount of an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. The present invention may be applied in the development of potent vaccines based on targeting vaccine antigens to antigen-presenting cells via binding to Fc gamma receptors.


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