The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Oct. 31, 2016
The U.s.a., As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Baylor College of Medicine, Houston, TX (US);
Lauren V. Wood, Bethesda, MD (US);
Brenda D. Roberson, Frederick, MD (US);
Jay A. Berzofsky, Bethesda, MD (US);
John C. Morris, Cincinnati, OH (US);
Jason C. Steel, Queensland, AU;
Masaki Terabe, Potomac, MD (US);
Malcolm K. Brenner, Houston, TX (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Baylor College of Medicine, Houston, TX (US);
Abstract
Recombinant adenoviruses expressing the extracellular (EC) and transmembrane (TM) domains of human HER2 (HER2ECTM) are described. The recombinant adenoviruses express a chimeric fiber protein having the adenovirus type 35 (Ad5) shaft and knob domains, which facilitates transduction of human dendritic cells by the recombinant HER2ECTM expressing adenovirus. Compositions that include dendritic cells transduced by the recombinant adenovirus and their use for treating HER-positive tumors is described.