The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Sep. 13, 2017
Applicant:
Academia Sinica, Taipei, TW;
Inventors:
Assignee:
ACADEMIA SINICA, Taipei, TW;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/545 (2015.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 5/0735 (2010.01); C12N 5/0775 (2010.01); C12N 5/074 (2010.01); C12N 5/0789 (2010.01);
U.S. Cl.
CPC ...
A61K 35/545 (2013.01); A61P 35/00 (2018.01); C07K 14/47 (2013.01); C07K 14/4702 (2013.01); C12N 5/0606 (2013.01); C12N 5/0647 (2013.01); C12N 5/0663 (2013.01); C12N 5/0665 (2013.01); C12N 5/0696 (2013.01); C12N 2501/125 (2013.01); C12N 2501/2303 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/60 (2013.01); C12N 2510/00 (2013.01);
Abstract
The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.