The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Mar. 23, 2018
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Harvey Lodish, Brookline, MA (US);
Hidde L. Ploegh, Brookline, MA (US);
Hsiang-Ying Sherry Lee, Cambridge, MA (US);
Jiahai Shi, Kowloon, HK;
Lenka Hoffman, Malden, MA (US);
Novalia Pishesha, Cambridge, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Abstract
Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.