The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2022
Filed:
Oct. 26, 2017
Method for increasing cell proliferation in pancreatic beta cells, treatment method, and composition
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Andrew F. Stewart, New York, NY (US);
Peng Wang, Fresh Meadows, NY (US);
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/44 (2006.01); A61K 31/425 (2006.01); A61K 31/40 (2006.01); A61K 31/519 (2006.01); A61P 1/18 (2006.01); A61P 3/10 (2006.01); A61K 31/4045 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61K 31/454 (2006.01); A61K 31/4709 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/4045 (2013.01); A61K 31/428 (2013.01); A61K 31/437 (2013.01); A61K 31/454 (2013.01); A61K 31/4709 (2013.01); A61P 1/18 (2018.01); A61P 3/10 (2018.01); C12N 5/0676 (2013.01); C12N 2501/999 (2013.01);
Abstract
The present invention relates to a method of increasing cell proliferation in a population of pancreatic beta cells and a method of treating a subject for a condition associated with an insufficient level of insulin secretion. Also disclosed is a composition. The composition includes a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1 A) inhibitor and a transforming growth factor beta (TGFP) superfamily signaling pathway inhibitor.