The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2022

Filed:

Mar. 07, 2019
Applicants:

The University of British Columbia, Vancouver, CA;

The General Hospital Corporation, Boston, MA (US);

Inventors:

Christian Kastrup, Vancouver, CA;

Ju Hun Yeon, Seoul, KR;

James Baylis, Vancouver, CA;

Thomas Frederick Burke, Medford, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/46 (2006.01); A61L 29/10 (2006.01); C01F 11/18 (2006.01); A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61L 29/16 (2006.01); A61L 31/08 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61L 15/18 (2006.01); A61L 15/44 (2006.01); A61K 38/18 (2006.01); A61K 38/48 (2006.01); A61L 15/20 (2006.01); A61L 15/42 (2006.01); A61L 29/08 (2006.01); A61L 29/14 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0007 (2013.01); A61K 9/143 (2013.01); A61K 9/145 (2013.01); A61K 9/1617 (2013.01); A61K 38/18 (2013.01); A61K 38/4833 (2013.01); A61L 15/18 (2013.01); A61L 15/20 (2013.01); A61L 15/425 (2013.01); A61L 15/44 (2013.01); A61L 29/08 (2013.01); A61L 29/10 (2013.01); A61L 29/106 (2013.01); A61L 29/146 (2013.01); A61L 29/16 (2013.01); A61L 31/08 (2013.01); A61L 31/082 (2013.01); A61L 31/088 (2013.01); A61L 31/146 (2013.01); A61L 31/16 (2013.01); C01F 11/18 (2013.01); A61L 2300/254 (2013.01); A61L 2300/418 (2013.01); A61L 2300/606 (2013.01); A61L 2400/04 (2013.01); A61L 2400/12 (2013.01); A61L 2420/06 (2013.01); C01P 2004/61 (2013.01); C01P 2006/16 (2013.01); C12Y 304/21005 (2013.01);
Abstract

A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 μm or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.


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