The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 08, 2022

Filed:

Sep. 22, 2016
Applicant:

University Health Network, Toronto, CA;

Inventors:

Arash Zarrine-Afsar, Toronto, CA;

David A. Jaffray, Etobicoke, CA;

Alessandra Tata, Rome, IT;

Michael Woolman, Toronto, CA;

Alexander Vitkin, Toronto, CA;

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/00 (2006.01); A61B 10/02 (2006.01); A61B 18/20 (2006.01); H01J 49/04 (2006.01); G01N 21/21 (2006.01); A61B 34/10 (2016.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61B 6/03 (2006.01); A61B 8/08 (2006.01); A61B 18/12 (2006.01); H01J 49/00 (2006.01); A61B 34/20 (2016.01); A61B 18/00 (2006.01);
U.S. Cl.
CPC ...
A61B 10/0266 (2013.01); A61B 5/0095 (2013.01); A61B 5/055 (2013.01); A61B 6/032 (2013.01); A61B 6/037 (2013.01); A61B 8/085 (2013.01); A61B 18/12 (2013.01); A61B 18/20 (2013.01); A61B 34/10 (2016.02); G01N 21/21 (2013.01); H01J 49/0004 (2013.01); H01J 49/0031 (2013.01); H01J 49/04 (2013.01); A61B 10/0233 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00595 (2013.01); A61B 2018/00904 (2013.01); A61B 2034/107 (2016.02); A61B 2034/2072 (2016.02);
Abstract

Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.


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