The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2022

Filed:

Jun. 18, 2019
Applicants:

Fluidigm Canada Inc., Markham, CA;

Paul Corkum, Markham, CA;

Inventors:

Paul Corkum, Ottawa, CA;

Alexander V. Loboda, Thornhill, CA;

Assignee:

FLUIDIGM CANADA INC., Markham, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
H01J 49/04 (2006.01); G01N 33/68 (2006.01); G02B 21/33 (2006.01); H01J 37/20 (2006.01); H01J 37/28 (2006.01); H01J 49/00 (2006.01); H01J 49/02 (2006.01); H01J 49/06 (2006.01); H01J 49/10 (2006.01); H01J 49/40 (2006.01); H01J 49/16 (2006.01); H01J 49/14 (2006.01);
U.S. Cl.
CPC ...
H01J 49/0463 (2013.01); G01N 33/6848 (2013.01); G01N 33/6851 (2013.01); G02B 21/33 (2013.01); H01J 37/20 (2013.01); H01J 37/28 (2013.01); H01J 49/0004 (2013.01); H01J 49/0031 (2013.01); H01J 49/025 (2013.01); H01J 49/0418 (2013.01); H01J 49/067 (2013.01); H01J 49/105 (2013.01); H01J 49/142 (2013.01); H01J 49/161 (2013.01); H01J 49/164 (2013.01); H01J 49/40 (2013.01);
Abstract

The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMCTM) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.


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