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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11262334 B1

PDFFull Text
Date of Patent:
Mar. 01, 2022

Filed:

Apr. 16, 2020

Methods for liquid chromatography fluidic monitoring

Applicant:

Thermo Finnigan Llc, San Jose, CA (US);

Inventors:

Tao Song, Milford, MA (US);

John E. Brann, Shrewsbury, MA (US);

Joseph John Takarewski, Jr., Brookline, MA (US);

Eric A. France, Quincy, MA (US);

Assignee:

THERMO FINNIGAN LLC, San Jose, CA (US);

Attorney:

Thomas F. Cooney

Primary Examiner:

Robert Clemente

Int. Cl.
CPC ...
G01N 30/32 (2006.01); B01D 15/16 (2006.01); G01N 30/24 (2006.01); G01N 30/20 (2006.01); G01M 3/28 (2006.01); G01M 3/32 (2006.01); B01D 15/14 (2006.01); B01D 15/42 (2006.01); B01D 35/143 (2006.01); G01N 30/88 (2006.01); G01N 35/00 (2006.01); G01N 35/10 (2006.01); G01N 30/34 (2006.01);
U.S. Cl.
CPC ...
G01N 30/32 (2013.01); B01D 15/14 (2013.01); B01D 15/16 (2013.01); B01D 15/163 (2013.01); B01D 15/424 (2013.01); B01D 35/1435 (2013.01); G01M 3/28 (2013.01); G01M 3/2815 (2013.01); G01M 3/3272 (2013.01); G01N 30/20 (2013.01); G01N 30/24 (2013.01); G01N 30/88 (2013.01); G01N 35/1002 (2013.01); G01N 35/1097 (2013.01); G01N 2030/326 (2013.01); G01N 2030/328 (2013.01); G01N 2030/347 (2013.01); G01N 2030/889 (2013.01); G01N 2035/009 (2013.01); Y10T 137/85978 (2015.04);
Abstract

A liquid chromatography monitoring system comprises a computer or electronic controller comprising computer-readable instructions operable to: (a) draw a fluid into a syringe pump; (b) configure a valve so as to fluidically couple the pump to either a fluidic pathway through a fluidic system or to a plug that prevents fluid flow; (c) cause the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determine a profile of the variation of the measured pressure; (e) compare the determined profile to an expected profile that depends upon the fluid; and (f) provide a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance.

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