The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Oct. 13, 2017
Applicant:
Promega Corporation, Madison, WI (US);
Inventors:
Ce Shi, Madison, WI (US);
Thomas Kirkland, Atascadero, CA (US);
Poncho Meisenheimer, San Luis Obispo, CA (US);
Lance P. Encell, Fitchburg, WI (US);
Mary Hall, Waunakee, WI (US);
Assignee:
Promega Corporation, Madison, WI (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/66 (2006.01); C12Q 1/00 (2006.01); C12N 9/02 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/66 (2013.01); C12N 9/0069 (2013.01); C12Q 1/008 (2013.01); C12Y 113/12007 (2013.01);
Abstract
Provided herein are inhibitor-resistant luciferase mutants, and methods of use thereof. In particular, luciferase mutants are provided that are thermal stable and exhibit improved stability in the presence of luciferin break-down products, such as dehydroluciferin. Further provided are assay systems comprising inhibitor-resistant luciferase mutants and amino acid sequences of the inhibitor-resistant luciferase mutants.