The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Sep. 19, 2017
Oncoc4, Inc., Rockville, MD (US);
Children's Research Institute, Children's National Medical Center, Washington, DC (US);
Yang Liu, Washington, DC (US);
Pan Zheng, Washington, DC (US);
Martin Devenport, Gaithersburg, MD (US);
Wei Wu, Washington, DC (US);
Xuexiang Du, Washington, DC (US);
Mingyue Liu, Washington, DC (US);
Fei Tang, Washington, DC (US);
ONCOC4, INC., Rockville, MD (US);
CHILDREN'S NATIONAL MEDICAL CENTER, Washington, DC (US);
Abstract
This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.