The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Feb. 12, 2018
The Research Institute of Fox Chase Cancer Center, Philadelphia, PA (US);
Rabd Biotech, Llc, Hatboro, PA (US);
Roland L. Dunbrack, Philadelphia, PA (US);
Jared Adolf-Bryfogle, Philadelphia, PA (US);
Gregory P. Adams, Hatboro, PA (US);
Matthew K. Robinson, Blue Bell, PA (US);
INSTITUTE FOR CANCER RESEARCH, Philadelphia, PA (US);
Abstract
Recombinant proteins that comprise a bone morphogenic protein 2 backbone onto which was grafted a Müllerian-inhibiting substance type II receptor binding region of the Müllerian-inhibiting substance protein are provided. These proteins bind to this receptor on the surface of epithelial cancer cells, and induce apoptosis of such cells. These proteins are useful, for example, in the treatment of cancers such as ovarian, uterine, endometrial, fallopian tube, breast, prostate, and lung cancers.