The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Sep. 17, 2018
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Inventors:
Amnon Hoffman, Jerusalem, IL;
Chaim Gilon, Jerusalem, IL;
Adi Klinger, Rishon Lezion, IL;
Johnny Naoum, Haifa, IL;
Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 7/64 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.