The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Jan. 11, 2019
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Daniel E. Kahne, Brookline, MA (US);
Vadim Baidin, Cambridge, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 5/02 (2006.01); A61P 31/04 (2006.01); C07C 211/27 (2006.01); C07C 211/40 (2006.01); C07C 215/28 (2006.01); C07D 209/04 (2006.01); C07D 213/38 (2006.01); C07D 213/643 (2006.01); C07D 215/06 (2006.01); C07D 215/12 (2006.01); C07D 221/04 (2006.01); C07D 221/20 (2006.01); C07D 231/12 (2006.01); C07D 231/56 (2006.01); C07D 239/26 (2006.01); C07D 239/34 (2006.01); C07D 261/08 (2006.01); C07D 267/10 (2006.01); C07D 295/13 (2006.01); C07D 307/14 (2006.01); C07D 307/79 (2006.01); C07D 307/87 (2006.01); C07D 309/04 (2006.01); C07D 311/74 (2006.01); C07D 317/58 (2006.01); C07D 319/08 (2006.01); C07D 327/06 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 493/08 (2006.01); C07D 495/04 (2006.01); C07D 498/08 (2006.01);
U.S. Cl.
CPC ...
C07F 5/027 (2013.01); A61P 31/04 (2018.01); C07C 211/27 (2013.01); C07C 211/40 (2013.01); C07C 215/28 (2013.01); C07D 209/04 (2013.01); C07D 213/38 (2013.01); C07D 213/643 (2013.01); C07D 215/06 (2013.01); C07D 215/12 (2013.01); C07D 221/04 (2013.01); C07D 221/20 (2013.01); C07D 231/12 (2013.01); C07D 231/56 (2013.01); C07D 239/26 (2013.01); C07D 239/34 (2013.01); C07D 261/08 (2013.01); C07D 267/10 (2013.01); C07D 295/13 (2013.01); C07D 307/14 (2013.01); C07D 307/79 (2013.01); C07D 307/87 (2013.01); C07D 309/04 (2013.01); C07D 311/74 (2013.01); C07D 317/58 (2013.01); C07D 319/08 (2013.01); C07D 327/06 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 493/08 (2013.01); C07D 495/04 (2013.01); C07D 498/08 (2013.01);
Abstract
Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.