The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2022

Filed:

Aug. 01, 2019
Applicant:

Genoscience Pharma, Marseilles, FR;

Inventors:

Philippe Halfon, Marseilles, FR;

Firas Bassissi, Marseilles, FR;

Sonia Brun, Aix en Provence, FR;

Jérôme Courcambeck, Marseilles, FR;

Madani Rachid, Saint-Cyr-sur-Mer, FR;

Assignee:

GENOSCIENCE PHARMA, Marseilles, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); C07D 487/04 (2006.01); C07D 207/02 (2006.01); C07D 215/02 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 207/02 (2013.01); C07D 215/02 (2013.01);
Abstract

2-primary amino-4-secondary amino-quinoline derivatives, their manufacture, pharmaceutical compositions comprising them and their use as medicaments are disclosed. The compounds are useful as a medicament in treating and/or decreasing the severity and/or progression and/or preventing fibrosis and/or related diseases, or for use as a medicament in treating, decreasing the severity and/or progression of and/or preventing autophagy and/or related diseases, for inhibiting autophagy flux, and for inhibiting cathepsins B (CTSB), L (CTSL) and/or D (CTSD) and/or related diseases.


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