The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Mar. 16, 2018
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Marsha A. Moses, Brookline, MA (US);
Peng Guo, Boston, MA (US);
Jiang Yang, West Lafayette, IN (US);
Debra Auguste, Briarcliff Manor, NY (US);
Daxing Liu, Stony Brook, NY (US);
Assignee:
Children's Medical Center Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 47/68 (2017.01); A61P 35/04 (2006.01); A61P 35/00 (2006.01); A61K 31/704 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6913 (2017.08); A61K 31/704 (2013.01); A61K 47/6849 (2017.08); A61K 47/6855 (2017.08); A61K 47/6915 (2017.08); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07K 16/2821 (2013.01); C07K 16/2863 (2013.01);
Abstract
The disclosure provides liposomes (e.g., cancer-targeting liposomes) with ligands (e.g., EGFR ligands and ICAM-1 ligands) conjugated to liposome surfaces. In some embodiments, the molecular ratio of different ligands complement the relative molecular density (i.e., ratio) of overexpressed protein on the surface of a cell targeted by the liposome (e.g., cancer cell).