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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11260129 B1

PDFFull Text
Date of Patent:
Mar. 01, 2022

Filed:

Feb. 02, 2017

Phosphor-containing drug activator, suspension thereof, system containing the suspension, and methods for use

Applicants:

Immunolight, Llc, Detroit, MI (US);

Duke University, Durham, NC (US);

Inventors:

Harold Walder, Belville, NC (US);

Frederic A. Bourke, Jr., Aspen, CO (US);

Zakaryae Fathi, Raleigh, NC (US);

Wayne Beyer, Bahama, NC (US);

Mark Oldham, Durham, NC (US);

Justus Adamson, Durham, NC (US);

Michael Nolan, Raleigh, NC (US);

Assignees:

IMMUNOLIGHT, LLC, Detroit, MI (US);

DUKE UNIVERSITY, Durham, NC (US);

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

Paul W Dickinson

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 41/00 (2020.01); A61K 31/37 (2006.01); A61N 5/06 (2006.01); A61N 5/10 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0066 (2013.01); A61K 31/37 (2013.01); A61N 5/062 (2013.01); A61N 5/10 (2013.01); A61K 45/06 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/1098 (2013.01);
Abstract

A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+ and (3Ca3 (PO4)2Ca(F, Cl)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.

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