The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
May. 20, 2016
Applicant:
Astellas Pharma Inc., Chuo-ku, JP;
Inventors:
Assignee:
Astellas Pharma Inc., Chuo-ku, JP;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); A61K 39/00 (2006.01); C12N 15/06 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12P 21/00 (2006.01); G01N 33/53 (2006.01); G01N 33/567 (2006.01); C07K 16/22 (2006.01); C12N 5/10 (2006.01); C07K 16/28 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 27/00 (2006.01); A61P 25/04 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39533 (2013.01); A61P 25/00 (2018.01); A61P 25/02 (2018.01); A61P 25/04 (2018.01); A61P 27/00 (2018.01); A61P 29/00 (2018.01); C07K 16/22 (2013.01); C07K 16/2875 (2013.01); C12N 5/10 (2013.01); C12N 15/09 (2013.01); A61K 2039/505 (2013.01); C07K 2317/40 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
To provide a superior anti-human NGF antibody Fab fragment that maintains a high neutralizing activity, and that reduces systemic side-effects arising from systemic exposure while expressing a local drug effect, and means for treating postoperative pain by using such antibody fragment. An anti-human NGF antibody Fab fragment comprising a heavy-chain fragment consisting of the amino acid sequence shown by SEQ ID NO:5 and a light-chain consisting of the amino acid sequence shown by SEQ ID NO: 8.