The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2022
Filed:
Apr. 04, 2019
Applicant:
3-d Matrix, Ltd., Tokyo, JP;
Inventors:
Takahiro Ochiya, Tokyo, JP;
Tomohiro Fujiwara, Tokyo, JP;
Assignee:
3-D Matrix, Ltd., Tokyo, JP;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61K 31/282 (2006.01); A61P 35/00 (2006.01); A61K 31/7115 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 31/282 (2013.01); A61K 31/7115 (2013.01); A61P 35/00 (2018.01); A61K 45/06 (2013.01);
Abstract
Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.