The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 22, 2022

Filed:

Feb. 11, 2020
Applicants:

Advanced Liquid Logic, Inc., San Diego, CA (US);

Duke University, Durham, NC (US);

Inventors:

Vamsee K. Pamula, Cary, NC (US);

Vijay Srinivasan, Cary, NC (US);

Michael G. Pollack, Durham, NC (US);

Richard B. Fair, Durham, NC (US);

Assignees:

Advanced Liquid Logic, Inc., San Diego, CA (US);

Duke University, Durham, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/26 (2006.01); B01F 13/00 (2006.01); B01L 3/00 (2006.01); B01L 7/00 (2006.01); G01N 35/00 (2006.01); C12Q 1/686 (2018.01); C12Q 1/6869 (2018.01); G01N 27/447 (2006.01); G01N 27/327 (2006.01); G01N 27/416 (2006.01); B01L 3/02 (2006.01);
U.S. Cl.
CPC ...
G01N 27/26 (2013.01); B01F 13/0071 (2013.01); B01F 13/0076 (2013.01); B01L 3/502715 (2013.01); B01L 3/502723 (2013.01); B01L 3/502761 (2013.01); B01L 3/502784 (2013.01); B01L 3/502792 (2013.01); B01L 7/525 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6869 (2013.01); G01N 27/3271 (2013.01); G01N 27/416 (2013.01); G01N 27/447 (2013.01); G01N 35/00029 (2013.01); B01L 3/0268 (2013.01); B01L 7/52 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/0673 (2013.01); B01L 2200/0684 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/089 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/1827 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0424 (2013.01); B01L 2400/0427 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0442 (2013.01); B01L 2400/0448 (2013.01); G01N 2035/00158 (2013.01); G01N 2035/00237 (2013.01);
Abstract

The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads.


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