The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2022
Filed:
Jul. 21, 2016
Almac Diagnostics Limited, Craigvon, GB;
Timothy Davison, Hillsborough, GB;
Jude O'Donnell, Galbally, GB;
Max Bylesjo, Belfast, GB;
Fionnuala Patterson, Belfast, GB;
Steve Deharo, Lisburn, GB;
Laura A. Hill, Lisburn, GB;
Katherine E. Keating, Magherafelt, GB;
Vitali Proutski, Hillsborough, GB;
Denis Paul Harkin, Dromore, GB;
Richard Kennedy, Belfast, GB;
Nicolas Goffard, Craigavon, GB;
Steven Walker, Craigavon, GB;
Laura Taggart, Craigavon, GB;
Eileen Parkes, Craigavon, GB;
Almac Diagnostics Services Limited, Craigvon, GB;
Abstract
An immune response subtype of cancer is associated with DNA damage which allows subjects to be stratified for particular therapies including immune therapies which may be combined with DNA damage therapeutics. A method for predicting responsiveness to an antagonist of an inhibitory immune checkpoint and/or an agonist of a stimulatory immune checkpoint comprises determining the expression level of at least one gene selected from Table 2B, 2A or 1 in a sample from the subject. The determined expression level is used to predict responsiveness to an antagonist of an inhibitory immune checkpoint and/or an agonist of a stimulatory immune checkpoint.