The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2022
Filed:
Oct. 03, 2017
Glaxosmithkline Intellectual Property Development Limited, Middlesex, GB;
Hella Bosteels, Stevenage, GB;
Shugui Chen, Collegeville, PA (US);
Kayeleigh Farrow, Stevenage, GB;
Richard Kucia-Tran, Stevenage, GB;
William John Kenneth Lewis, Stevenage, GB;
Andrew S. Thomson, Collegeville, PA (US);
Mark Uden, Stevenage, GB;
Abstract
The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.