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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11254682 B1

PDFFull Text
Date of Patent:
Feb. 22, 2022

Filed:

Jul. 20, 2020

Small molecule myristate inhibitors of bcr-abl and methods of use

Applicants:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Nathanael S. Gray, Boston, MA (US);

Jianming Zhang, Belmont, MA (US);

Barun Okram, San Marcos, CA (US);

Xianming Deng, Fujian, CN;

Jae Won Chang, San Diego, CA (US);

Amy Wojciechowski, Cheektowaga, NY (US);

Assignees:

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);

DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);

Attorneys:

Crowell & Moring, LLP

Yuezhong Feng

Primary Examiner:

Susanna Moore

Int. Cl.
CPC ...
C07D 473/34 (2006.01); C07D 487/04 (2006.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); C07D 239/94 (2006.01); A61P 9/00 (2006.01); A61P 19/00 (2006.01); A61P 17/00 (2006.01); C07D 239/42 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 417/04 (2006.01); C07D 495/04 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/5377 (2006.01); A61K 31/7076 (2006.01); A61K 45/06 (2006.01); C07D 471/04 (2006.01); C07H 19/16 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 31/5377 (2013.01); A61K 31/7076 (2013.01); A61K 45/06 (2013.01); A61P 9/00 (2018.01); A61P 17/00 (2018.01); A61P 19/00 (2018.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07D 239/42 (2013.01); C07D 239/94 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 473/34 (2013.01); C07D 495/04 (2013.01); C07H 19/16 (2013.01); Y02A 50/30 (2018.01);
Abstract

The present disclosure provides novel heteroaryl compounds of formula (IV). Such compounds are useful for the treatment of cancers.

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