The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2022
Filed:
Sep. 17, 2019
Applicant:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Inventors:
Michael Chorny, Huntington Valley, PA (US);
Ivan Alferiev, Clementon, NJ (US);
Garrett M. Brodeur, Wynnewood, PA (US);
Assignee:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/60 (2017.01); A61K 31/4745 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 31/4745 (2013.01);
Abstract
Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.