The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2022
Filed:
Jun. 12, 2018
Korea Research Institute of Chemical Technology, Daejeon, KR;
Kwangho Lee, Daejeon, KR;
Inji Shin, Daejeon, KR;
Gildon Choi, Daejeon, KR;
Chong Hak Chae, Daejeon, KR;
Hyeon Jeong Choe, Daejeon, KR;
Myoung Eun Jung, Daejeon, KR;
Byeong Uk Jeon, Boryeong-Si, KR;
Byoung Chul Cho, Seoul, KR;
Chae Won Park, Seoul, KR;
Hwan Kim, Seoul, KR;
Krishna Babu Duggirala, Daejeon, KR;
Korea Research Institute of Chemical Technology, Daejeon, KR;
Abstract
The present invention relates to a N2,N4-diphenylpyrimidin-2,4-diamine derivative, a method for preparing the same, and a pharmaceutical composition for the prevention or treatment of cancer, containing the same as an active ingredient. The derivative shows a relatively weak EGFR activity inhibitory effect on wild-type EGFR, a high inhibitory ability on EGFR mutation, and a high inhibitory ability on even FLT3 and FLT3 mutation, and thus, can be effectively used for the treatment of cancer with EGFR mutation or cancer with FLT3 or a mutation thereof, and the derivative shows a synergy effect at the time of combination administration, and thus can be effectively used for the treatment of combination administration.