The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
May. 10, 2019
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Jose Baselga, New York, NY (US);
Eneda Toska, Edgewater, NJ (US);
Scott Armstrong, Wayland, MA (US);
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61P 35/00 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C12N 2310/122 (2013.01); C12N 2320/31 (2013.01);
Abstract
The presently disclosed subject matter relates to the administration of a KMT2D inhibitor for the treatment of a cancer. The present invention is based on the discovery that upon PI3K inhibition, KMT2D activity is upregulated, resulting in an increase in the expression of genes involved in breast cancer cell proliferation and tumor growth. Accordingly, the present invention provides methods for treating a subject that has cancer by administering a therapeutically effective amount of an KMT2D inhibitor.