The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 15, 2022

Filed:

May. 20, 2019
Applicants:

Ipsen Bioinnovation Limited, Abingdon, GB;

Allergan, Inc., Irvine, CA (US);

Inventors:

Peter James, Abingdon, GB;

Keith Foster, Abingdon, GB;

John Chaddock, Abingdon, GB;

Roger Aoki, Irvine, CA (US);

Lance Steward, Irvine, CA (US);

Joseph Francis, Irvine, CA (US);

Assignees:

Ipsen Bioinnovation Limited, Abingdon, GB;

Allergan, Inc., Irvine, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01); A61K 47/65 (2017.01); A61K 38/00 (2006.01); C07K 14/575 (2006.01); A61K 47/64 (2017.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); A61K 47/64 (2017.08); A61K 47/65 (2017.08); C07K 14/575 (2013.01); C12N 15/625 (2013.01); C12Y 304/21072 (2013.01); C12Y 304/24068 (2013.01); C12Y 304/24069 (2013.01); A61K 38/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/50 (2013.01); C07K 2319/55 (2013.01); C07K 2319/74 (2013.01); C12Y 304/24013 (2013.01);
Abstract

Single chain polypeptide fusion protein, comprising: a non-cytotoxic protease capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin targeting moiety; a protease cleavage site; a translocation domain; a first spacer located between the non-cytotoxic protease and the protease cleavage site; and a second spacer located between the galanin targeting moiety and the translocation domain.


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