The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
Jan. 17, 2020
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Dongeun Huh, Villanova, PA (US);
Cassidy Blundell, Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/078 (2010.01); C12N 5/073 (2010.01); C12M 1/34 (2006.01); G01N 33/50 (2006.01); C12M 3/06 (2006.01); C12M 1/12 (2006.01); C12M 1/42 (2006.01); B81C 1/00 (2006.01); B81B 7/00 (2006.01); B81B 3/00 (2006.01); B01D 63/08 (2006.01);
U.S. Cl.
CPC ...
C12M 23/16 (2013.01); B01D 63/088 (2013.01); B81B 3/00 (2013.01); B81B 7/00 (2013.01); B81C 1/00 (2013.01); C12M 25/02 (2013.01); C12M 35/08 (2013.01); C12M 41/30 (2013.01); C12N 5/0605 (2013.01); C12N 5/0634 (2013.01); G01N 33/5005 (2013.01); C12N 2502/025 (2013.01); C12N 2503/04 (2013.01);
Abstract
The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e., intervillous space). The microfluidic device can reconstitute the maternal-fetal interface, can expand the capabilities of cell culture models, and can provide an alternative to current maternal-fetal transfer models.