The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
Dec. 28, 2018
Applicant:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Inventors:
Philippe Crine, Outremont, CA;
Guy Boileau, Brossard, CA;
Isabelle Lemire, Montreal, CA;
Thomas P. Loisel, Montreal, CA;
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/06 (2006.01); C07K 14/51 (2006.01); C12N 9/16 (2006.01); C12N 9/64 (2006.01); A61K 47/64 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A61K 47/645 (2017.08); C07K 14/51 (2013.01); C12N 9/16 (2013.01); C12N 9/6421 (2013.01); C12N 9/6494 (2013.01); C12Y 304/24011 (2013.01); A61K 38/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/23 (2013.01); C12Y 301/03001 (2013.01);
Abstract
A bone delivery conjugate having a structure selected from the group consisting of: A) X-D-Y-protein-Z; and B) Z-protein-Y-D-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dis a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.