The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
Mar. 08, 2018
Cornell University, Ithaca, NY (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Nathanael S. Gray, Boston, MA (US);
David A. Scott, Newton, MA (US);
John Hatcher, Marlborough, MA (US);
Ari M. Melnick, New York, NY (US);
Lorena Fontan Gabas, New York, NY (US);
Cornell University, Ithaca, NY (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
Provided herein are compounds that inhibit MALT1, a protein whose activity is responsible for constitutive NF-κB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating MALT1-related diseases and disorders (e.g., cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.