The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
Oct. 05, 2018
Forma Therapeutics, Inc., Watertown, MA (US);
Justin Caravella, Cambridge, MA (US);
Bingsong Han, Westwood, MA (US);
Cuixian Liu, Madison, CT (US);
Stephanos Ioannidis, Natick, MA (US);
Alexandre Joseph Buckmelter, Acton, MA (US);
David James Richard, Littleton, MA (US);
Matthew W. Martin, Arlington, MA (US);
Steven Mischke, Waltham, MA (US);
Scot Mente, Watertown, MA (US);
FORMA Therapeutics, Inc., Watertown, MA (US);
Abstract
The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Protease 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments. Chemical entities disclosed herein include compounds of Formula (II): wherein A, R, R, R, R, R, R, R, R, and m are defined herein.