The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 15, 2022

Filed:

Jan. 21, 2020
Applicants:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

National Institutes of Health, a Component of the United States Department of Health and Human Services, Bethesda, MD (US);

The Regents of the University of California, Oakland, CA (US);

Inventors:

Donna M. Huryn, Allentown, NJ (US);

Peter Wipf, Pittsburgh, PA (US);

Matthew G. LaPorte, Pittsburgh, PA (US);

Raffaele Colombo, Pittsburgh, PA (US);

Marina Kovaliov, Pittsburgh, PA (US);

Chaemin Lim, Pittsburgh, PA (US);

Celeste Natalie Alverez, Pittsburgh, PA (US);

Zhizhou Yue, Pittsburgh, PA (US);

Lalith Palitha Samankumara, Pittsburgh, PA (US);

Alexander Julian Chatterley, Pittsburgh, PA (US);

Yongzhao Yan, Pittsburgh, PA (US);

Mary Liang, Pittsburgh, PA (US);

Neal J. Green, Newton, MA (US);

Eric T. Baldwin, Upper Holland, PA (US);

William J. Moore, Hagerstown, MD (US);

Michelle Arkin, San Francisco, CA (US);

R. Jeffrey Neitz, Oakland, CA (US);

Kean-Hooi Ang, Oakland, CA (US);

Clifford Bryant, Oakland, CA (US);

Stacie Bulfer, Oakland, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/10 (2006.01); A61P 35/00 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); A61P 25/28 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61P 25/28 (2018.01); A61P 35/00 (2018.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.


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