The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2022
Filed:
Jan. 18, 2019
Abbott Diabetes Care Inc., Alameda, CA (US);
Cambridge Enterprise Limited, Cambridge, GB;
Malgorzata E. Wilinska, Cambridge, GB;
Erwin S. Budiman, Fremont, CA (US);
Gary A. Hayter, Oakland, CA (US);
Marc B. Taub, Mountain View, CA (US);
Roman Hovorka, Cambridge, GB;
Abbott Diabetes Care Inc., Alameda, CA (US);
Abstract
A closed-loop system for insulin infusion overnight uses a model predictive control algorithm ('MPC'). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System ('FSN'). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery.